South Carolina’s most popular lakes including Lake Murray, Lake Hartwell, Lake Marion, and J. Strom Thurmond Reservoir. Lake Marion is the largest lake in South Carolina, located a short drive from Columbia, a city which receives a large percentage of its water supply because of it. The lake is referred to as South Carolina’s inland sea. The lake covers an area of 78 square miles with 620 miles of shoreline for popular activities like boating, sailing, canoeing, fishing, water skiing, swimming and camping. Clarks Lake is another terrific place to enjoy South Carolina lake cabins and cottages on breezy summer days. Even with a long Atlantic coastline, South Carolina comes through on lakeside cottage and cabin rentals too!